How to optimize choice of smart drugs, individually?
Generally, we want to improve our mental abilities, as this is useful for all kind of goals. However, it remains a difficult problem. For example, some smart drugs may decrease longevity (we should have a category for that, too), which reduces the likelyhood of reaching both the technological singularity, and the longevity escape velocity. On the other hand, using smart drugs may increase the mental acuity, that may enable the very breakthroughs needed to overcome problems in general.
The choice of neuro-modulation strategies is broad, each individual is unique, and, by the amount we are taking, food has to count as one of the key elements of that too, as we are playing the "tetris of life", to optimize our organism's metabolic and signaling "shapeflows".
So, the problem is -- how to intelligently choose what and when to eat. When playing tetris -- it is not good to have the same bricks falling all the time, in most cases. An organism benefits from variation of ingested substances over time, to clear the metabolytes, and so, we should vary diet and supplementation, question is -- how?